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Methods: The expression of senescent markers (p16 INK4a and p21 WAF1/Cip1 ), various SASPs such as CCL2 and interferon induced protein with tetratricopeptide repeats 3 (IFIT3), dysregulated autophagy marker p62 and PD-L1 were immunohistochemically examined in livers taken from the patients with PBC (n=87