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In an animal study, Brasil et al

The imbalance between proliferation and apoptosis is one of the most important pathogenic mechanisms of BPH

Desacyl-ghrelin concentrations were determined by ELISA (Bertin Pharma, Montigny-le-Bretonneux France)

We observed knockdown of NRF2 protein and robust growth inhibition upon dox treatment, highlighting the dependency of these cell lines on NRF2 for growth (Fig