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In order to investigate whether elevated levels of reduced GSH were due to less redox active heme iron being liberated from impaired hemoglobin uptake and digestion in resistant parasites, 24 hpi trophozoite-stage parasites were treated for 3 h with 10 M of the cysteine protease inhibitor, E64d, to block hemoglobin digestion and decrease free heme levels

Among the affected organs, the cardiovascular system is subjected to severe stress during sepsis, often culminating in what is referred to as septic cardiomyopathy, a finding well-supported by pre-clinical research 2,3

FDX1 enhances endometriosis cell cuproptosis via G6PD-mediated redox homeostasis

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