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33 Hypomethylation of microRNA-203, for example, downregulates the expression of the FA adhesome, leading to ECM remodeling and increased VSMC stiffness via an altered FAK/Src pathway 33

Visual quantification is time-consuming and subject to interobserver variability

Subcutaneous injection offers bioavailability of approximately 15-20% based on animal data, while intramuscular administration may provide 45-50% bioavailability in some species

SNP-specific F-statistics were calculated to evaluate the instrumental efficiency of SNPs with R 2 , exposure sample size, and the number of SNPs (Supplementary Table S1) ( Statistical analysis An inverse-variance weighted (IVW) analytical approach was applied to provide MR estimation and showed the largest statistical power among all MR methods by combining each Wald ratio of multiple SNPs ( 0