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Among these pathways, the Notch cascade, which is physiologically implicated in the differentiation of bipotent hepatoblasts into cholangiocytes, and therefore in biliary development, stands out as a critical player in lineage commitment towards the malignant cholangiocellular phenotype 134,135

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GHK-Cu is a copper-binding peptide compound widely referenced in preclinical and laboratory research for its interaction with cellular signalling and regenerative pathways