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Reference Magdeldin, Sameh, ed

Loss-of-function TNSALP mutations lead to ineffective PLP dephosphorylation to pyridoxal, reduced pyridoxal transfer into the brain, and accumulation of PLP in blood ( Several proteins are involved in the formation of GPI anchors that tether extracellular tissue non-specific alkaline phosphatase to the cell membrane

Although selenium supplementation demonstrates potential benefits in reducing autoantibody levels, the existing body of researchprimarily limited to short-term observations of 36 monthsfails to establish a definitive causal relationship between decreased antibody titers and sustained functional improvements in the neurological system (44, 264)

Therefore, a transformative approach for treating PF is the use of inhalation nano-based medication delivery devices