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Unlike most vitamins, B12 has a uniquely complex absorption pathway: Stomach acid and pepsin release B12 from food proteins B12 binds to R-proteins (haptocorrins) in saliva and stomach Pancreatic enzymes release B12 from R-proteins in the small intestine B12 binds to intrinsic factor (produced by gastric parietal cells) The B12-intrinsic factor complex is absorbed in the terminal ileum A breakdown at any of these five steps causes deficiency which is why B12 deficiency is far more common than dietary intake alone would predict

Health Canada has issued multiple public advisories since 2023 on unauthorized injectable peptide products, with BPC-157 named explicitly on the list of seized substances in actions against Canlab Research, Prime Research, and other vendors

It also follows the approval of Bristol Myers Squibb and 2seventy Bios Abecma in third line multiple myeloma

For instance, if you reconstitute a Reta 50mg vial with just 1mL of water, the resulting 50,000mcg/mL concentration requires measuring micro-volumes