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[DOI] [PMC free article] [PubMed] [Google Scholar] [117].Milinovich GJ, Burrell PC, Pollitt CC, Klieve AV, Blackall LL, Ouwerkerk D, et al

Intervention trials with folic acid have consistently shown a reduction in plasma homocysteine in humans, and it is well reported that alcohol is a known adversary of folate concentration in the human body

Extreme temperatures can compromise the efficacy of insulin, leading to potential fluctuations in blood glucose control

Conclusions Collectively, the evidence presented in this paper demonstrates how adverse early experiences interact with neurobiological processes to increase susceptibility to depression and suicidality