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Trimethylamine N Oxide in Relation to Cardiometabolic HealthCause or Effect ? Trimethylamine N Oxide in Aquatic Foods Journal of Agricultural and Food Chemistry Frontiers Implications of trimethylamine N oxide (TMAO) and Betaine in Human Health: Beyond Being Osmoprotective Compounds Trimethylamine N Oxide: Friend, Foe, or Simply Caught in the Cross Fire? ScienceDirect

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Second, while this study proposes a mechanistic hypothesis based on proteomic findings, future studies using immunohistochemistry and cellular co-localization are needed to identify the cellular sources of CINC-3 and CNTF expression and clarify DPs cellular targets.Thirdly, this study is the absence of behavioral assessments such as von Frey test, weight bearing, or gait analysis, future studies will incorporate these approaches to further investigate the functional implications of the molecular changes observed

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