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Accurate comprehension of the WADA Prohibited List structure and scope is critical for athletes and supplement manufacturers to avoid inadvertent anti-doping rule violations and safeguard athletic eligibility and brand reputation

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Converging information on the enzymology of GPX4 and the mechanism of LPO suggests that LPO is initiated by decomposition of hydroperoxide derivatives of lipids (LOOH) by ferrous iron leading to ferroptotic cell death