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BOX1: Complexity of genetic alterations and metabolism in PDAC In addition to the most frequent oncogenic somatic mutation KRAS , a high percentage of patients carry inactivating somatic mutations in the tumor suppressors cyclin-dependent kinase inhibitor 2 A ( CDKN2A ), tumor protein 53 ( TP53 ), and SMAD family member 4 ( SMAD4 ) [113,114,115], reinforcing their roles during PanIN-to-PDAC [116]

[DOI] [PubMed] 192.Hao J, Zhou J, Hu S, Zhang P, Wu H, Yang J, et al

Smoking rapidly uses up glutathione in the lungs and throughout the body as it tries to neutralize the multitude of free radicals in cigarette smoke