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DNA methylation and depression Studies have found that stress-related MDD is associated with DNA methylation changes in multiple human genes

Sakers A, De Siqueira MK, Seale P, Villanueva CJ

Additionally, DUSP4 KO mice display increased serum levels of insulin-like growth factor 1 (IGF-1), which subsequently induces the IGF-1AKT pathway in the liver of DUSP4 KO mice [73]

When quercetin was administered over a longer duration (1428 days and 28 days) of intervention, it had a significant effect on serum glucose levels with a shorter duration (Bule et al., 2019)