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In response, the endothelial cells at the leading edge of capillary growth are converted into tip cells, which are highly proliferative and can migrate towards the angiogenic signals (36,37)

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J Biol Chem 301:110571 Artuc M, Bohm M, Grutzkau A, Smorodchenko A, Zuberbier T, Luger T, Henz BM (2006) Human mast cells in the neurohormonal network: expression of Pomc, detection of precursor proteases, and evidence for Ige-dependent secretion of alpha-Msh

Thus, we analyze how organisms, ranging from single cells to humans, respond to various forms of hypoxia and how these responses influence regenerative processes with significant biomedical implications