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We found robust neurodegenerative features in cognitively impaired aged degus, including hippocampal neuronal loss, altered parvalbumin and perineuronal net staining in the cortex, and increased c-Fos neuronal activation in the cortex that is consistent with the neural circuit hyperactivity that are commonly reported in human Alzheimers Disease patients, explained corresponding author Xiangmin Xu, PhD, professor and Chancellors Fellow of anatomy and neurobiology in the UCI School of Medicine, and director of the Center for Neural Circuit Mapping

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This review focuses on the pleiomorphic clinical presentations and the genetic substrate of FIC and proposes a possible diagnostic and therapeutic work-up for this group of diseases, considering the shared factors and therapeutic novelties that may affect them

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Structural basis of inhibition of insulin-regulated aminopeptidase by a macrocyclic peptidic inhibitor

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Returning the reconstituted vial to the freezer: Freezing reconstituted peptide can cause ice crystal formation that damages the peptide

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