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Several age-regulated proteins identified by this work have been associated with age-related decrements of hippocampus-dependent learning and memory and increased oxidative stress, suggesting a potential mechanistic role for dysregulation of these proteins in functional deficits with hippocampal aging (Chen et al., In addition to studying the expression of proteins, it is also important to identify changes in protein post-translational modifications as they play integral roles not only in protein localization and function, but also in the pathogenesis of a variety of conditions including age-related disease

This is repeated every 3 to 6 months, depending on the physicians recommendation

RCT (Frye et al., 2016) A 12-week double-blind trial evaluated high-dose leucovorin in children with ASD and language delay [1]

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