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The generated ROS can trigger the Mitogen-activated protein kinase signaling route (MAPK), thereby activating p38 MAPK, ERK, and JNK, leading to glomerulosclerosis, renal interstitial fibrosis, damage caused by oxidative stress, pancreatic -cell apoptosis, inflammatory responses, and increased collagen synthesis in cells

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By contrast, hesperetin inhibits ferritinophagy and mitigates ferroptosis by modulating the PI3K/AKT/mTOR/ULK1 pathway (100), further underscoring the context-dependent role of ULK1