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Review Article | DOI: Cagrilintide Combined with Semaglutide: A New Approach for Treatment of Obesity and Type 2 Diabetes Endocrinology Division, Department of Medicine Olive View-UCLA Medical Center, David-Geffen UCLA Medical School, CA, USA

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Further epigenetic evaluation revealed reductions in three histones (H3Ac, H4Ac, H3K4me3) that transcriptionally activate insulin-2 gene promoters and significant elevation in two histones (H3K9me3, H3K20me3) that suppress/silence these promoters [172]