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A peptide losing 50% potency effectively costs twice as much per effective dose

Finally, NL2 intracellular interactions with 2 subunit of GABA A R stabilize both molecules at inhibitory synapses (Dong et al., 2007)

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G protein-coupled receptors (GPCRs), also called seven-(pass)-transmembrane domain receptors, seven-(pass)-transmembrane domain receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), are a large family of evolutionarily related proteins that are cell surface receptors that recognize molecules outside the cell and trigger cellular responses