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The average weight loss after 72 weeks of treatment was 1520% (compared to 3.1% with a placebo), and 3057% of participants lost at least 20% of their body weight [118]

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Acknowledgements This review was supported by the National Natural Science Foundation of China (82373039) and the University-Industry Collaboration Program (New Drug Targets and New Molecule Discovery and Technology 8210040001, 2020-019)

PERK controls bone homeostasis through the regulation of osteoclast differentiation and function