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*Correspondence: Shaobin Wei [email protected] These authors have contributed equally to this work These authors share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

At physiological pH, H 2 S exists mainly as a hydrosulfide anion (HS , 7580%), with the remainder in the form of the dissolved uncharged H 2 S gas (~2025%) and negligible amounts of S 2 8

Autophagy is a self-protective mechanism and plays a vital role in regulating cell survival and death

One study found L-citrulline protected against renal ischemia-reperfusion injury through the nitric oxide pathway, where glutathione plays a critical role in protecting NO from degradation