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Description

In contrast to most terminally differentiated somatic cells, adult stem cells undergo extensive proliferation and differentiation processes, increasing the likelihood of DNA damage during DNA replication

The samples were placed under -ray irradiation (01000 Gy) from a 137 Cs radiation source

These results suggest that ZOTs could be most effective in GBM cells with wild-type TP53 and mutated PTEN , a genotype common in IDH-wildtype GBM (~ 90% of adult gliomas) 68