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Foundational NNMT Discoveries The foundational research establishing NNMT as a metabolic regulator and potential therapeutic target came from studies by Daniel Kraus and colleagues published in Nature in 2014, which demonstrated that NNMT expression is dramatically upregulated in adipose tissue of obese humans and diet-induced obese mice, and that genetic knockdown of NNMT in mice protected against diet-induced obesity and improved metabolic parameters

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The vasoprotective effects align neatly with the mechanistic picture: a compound that promotes angiogenesis and modulates nitric oxide would predictably stabilize vascular function across a range of stressors

The disease is usually transmitted from an infected immature black-legged tick (also known as deer tick) to humans through a bite