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Whereas guanidine was shown to exhibit anti-diabetic effects in animals, its toxicity made it unsuitable for clinical use, and whilst galegine had a lower toxicity, it failed to deliver the same significant anti-diabetic activity

The biological activities described above also characterize Met functions in the brain where HGF/c-Met signaling is neurotrophic (Honda et al., 1995) and protective (Zhang et al., 2000