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discovered that chronic hypoxia-induced PAH is associated with the suppression of Kv channel expression and function in PASMCs, leading to a shift in the cellular redox balance toward a more reduced state

10 siRNA therapies including olpasiran, zerlasiran, and lepodisiran have demonstrated significant Lp(a) reductions, with olpasiran achieving up to 101.1% placebo-adjusted reduction in the phase 2 OCEAN(a) DOSE trial, lepodisiran up to 97% reduction with the maximal dose in the phase 1 study, 93 and zerlasiran showing a 96.4% reduction in the recently published phase 2 trial

29 Additionally, a sensitivity analysis was conducted by adjusting the Vp and Q values based on the 95% confidence intervals reported in the literature, with the confidence interval for Vp ranging from 1.71 to 2.13 and for Q ranging from 74.0 to 84.3

In: GantaitSMajumderJSharangiAB, editors