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Second-generation rabies virus-based vaccine vectors expressing human immunodeficiency virus type 1 gag have greatly reduced pathogenicity but are highly immunogenic

In an effort to bring cellular clarity to our analyses, and to investigate UMNs direct response to treatment, we took advantage of the prpTDP-43 A315T -UeGFP mice, a CSMN reporter line in which diseased UMNs in mice that have TDP-43 pathology retain their fluorescence both in vivo and in vitro

While four studies showed large effect sizes and UPDRS scores indicating improvement in PD symptoms, only three of these were statistically significant

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