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Basal serum concentrations of the endocannabinoid ligands N-arachidonylethanolamide and 2-arachidonoylglycerol were significantly reduced in women with major depression relative to matched controls, indicating a deficit in peripheral endocannabinoid activity (Hill et al., 2009)

GI disorders, gastrointestinal disorders

Role in bioactivation and detoxication mechanisms of xenobiotics

This analysis showed similar levels of PCC in patient and control fibroblasts indicating that in patient fibroblasts, despite the UPR and the possible generation of high levels of ROS, efficient CAT/SOD antioxidant defences prevent protein damage (Fig