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doi: 10.1530/JME-15-0124 263 CarpenterJRJablonskiKAKoncinskyJVarnerMWGyamfi-BannermanCJoss-MooreLAet al

Overexpression of HGF retards disease progression and prolongs life span in a transgenic mouse model of ALS

Additionally, ABCC1 is found to be indirectly upregulated by the silenced CUL3 KEAP1 E3 ligase in breast cancer, stabilizing nuclear factor erythroid 2-related factor 2 (NRF2), and subsequently increases NRF2-regulated ABCC1 transcription, which exhibits resistance to both doxorubicin and paclitaxel [64]