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Using it undiluted intravenously is contraindicated for this reason

Similar to Wnt9a, sonic hedgehog was upregulated in the tubular epithelium of patients with proteinuric kidney diseases, such as IgA nephropathy, membranous nephropathy and focal segmental glomerulosclerosis (81), as it was in animal models of CKD induced by ischemia/reperfusion injury, adriamycin, renal mass ablation, or diabetes mellitus (81, 82)

We suspect that this may have been a sample that was taken shortly after the GBCA had been administered

Further longitudinal studies are required to examine changes in BBB permeability over time and in other postviral illnesses