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Twenty-four-week-old DIO mice (Jackson Laboratories) were fed a HFD (Research Diets, D12492) for 18 weeks and dosed with vehicle (5% DMSO and 0.5% hydroxypropyl methylcellulose in phosphate-buffered saline), TLC-6665 (5 mg per kg (body weight)) or pioglitazone (30 mg per kg (body weight)) once daily by oral gavage for 4 weeks