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Pannexin-1 channels are increasingly recognized as conduits for ATP release, and experimental blockade of Panx1 has been shown to attenuate peripheral inflammatory pain, underscoring their contribution to nociceptive amplification when inflammation is present [43,45]

Results were published in the New England Journal of Medicine in September 2025

[The Working Group noted that the study was subject to several potential biases, including selection bias (only 23% of the eligible cases participated), unclear exposure assessment, and a very small number of cases ( n = 54), and was therefore considered to be uninformative (results were null).] [The main development in the design of the studies was the evolution from casecontrol studies to cohort studies

This release stimulates cortisol secretion from the adrenal glands, which is necessary for controlling the body's stress response and maintain energy balance and immune function