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Furthermore, physiologically relevant concentrations of bilirubin provide protection against protein- and lipid-induced myeloperoxidase-generated hypochlorous acid oxidation, suggesting that this inhibition is accompanied by direct scavenging of chloramines by albumin-bound bilirubin (Sameiro-Faria et al., 2014

In order to mimic the natural increase of SHs and their effect on GH/IGF-1 axis and skeletal growth, male patients with DSD and hypogonadism need to start testosterone therapy during pubertal age