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As these studies implicated disulfiram as a potential antileukemia drug, we therefore undertook full doseresponse resazurin reduction-based viability assays to thoroughly characterize the effects of the drug in a larger and more diverse panel of cells comprised of acute leukemia cell lines ( n = 16), solid cancer cell lines ( n = 7), and non-malignant cells ( n = 2)

Intriguingly, a Western diet high in PUFAs can induce intestinal inflammation in mice lacking one allele of GPX4 in IECs, which implies that dietary PUFAs may be a trigger of GPX4-restricted mucosal inflammation phenocopying aspects of human CD (143)

Topical antioxidants such as CE ferulic acid can be considered in selected cases when patients understand the role of sunscreens & primary pigment correctors

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