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Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging

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Antonoff, MB, Rice DC

Indeed, women affected by premature menopause under 40 years of age and who did not receive estrogens treatment show an increased risk of developing cardiovascular and neurodegenerative disorders, which correlate with an increase in mortality (Shuster et al., 2010)