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Linster et al

The reasons for a vitamin B12 deficiency are manifold: Unfavourable eating habits (for example fast food and convenience food), absorption disorders in older age, a strict vegetarian diet or certain intestinal diseases are frequent causes

The resultant effect is an increase in oxidative stress through increasing homocysteine levels, and whilst both oxidative stress and gradual hypomethylation are markers of Alzheimers, more work is needed to determine the severity of the effect of folate deficiency in adulthood on this disease [160]