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These observations indicate that SLC25 transporters exhibit considerable functional redundancy and that phenotypes can be unmasked only by combinatorial screening under different conditions

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AML cells treated with venetoclax have upregulated heme biosynthesis which is an important regulator of mitochondrial-related apoptosis through ETC and OXPHOS (62)

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(2012) demonstrated that long-term exposure to CP impaired autophagy leading to CP resistance, and interestingly, upregulation of autophagic response under such condition re-sensitized resistant cells to CP-induced cell death