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Discussion The available clinical experiences on the use of vitamins to treat chronic viral hepatitis, either alone or in combination with IFN-based therapies, are inconsistent and hampered by major methodological drawbacks, such as small sample size, the lack of double-blinding or placebo controls, the heterogeneous features of patients and the use of surrogate endpoints

Suitable participants could be those facing planned ischemic events, such as heart surgery, organ transplants, or procedures to restore blood flow