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Description

Department of Nephrology, Affiliated Renhe Hospital of China Three Gorges University, Yichang, Hubei, China

Guyon A (2014)

ER signaling can inhibit ferroptosis by enhancing antioxidant defenses through NRF2 stabilization, GPX4 upregulation, and regulation of iron metabolism, or promote ferroptosis by activating NOX1 and increasing ROS production

A further preferred embodiment is a nucleic acid molecule comprising a nucleotide sequence which is at least 95% identical to the nucleotide sequence of SEQ ID NO:1 beginning with the nucleotide at about the position of the 5 NT of ORF and ending with the nucleotide at about the position of the 3 NT of ORF as defined for SEQ ID NO:1 in Table I