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The average differences are not very large, but they are big enough and occurring over a short enough time period to be the cause of some concern. These demonstrated population-level declines are greater than the cross-sectional declines typically associated with age, according to the researchers

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TB-500 specifically has limited published human data, though practitioner reports over the past decade consistently describe faster recovery from soft tissue injuries

Commenters stated that excimer laser treatment requires a high amount of skill and precision to perform to ensure that healthy tissues are not damaged, and the procedure causes significant pain that requires patients to have numbing agents applied to their lesions