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Apocynin alleviates lung injury by suppressing NLRP3 inflammasome activation and NF-B signaling in acute pancreatitis

The arachidonate lipoxygenase (ALOX) family is a class of non-heme iron-containing enzymes that can catalyze polyunsaturated fatty acids (PUFAs) oxygenation to generate various hydroperoxy PUFA derivatives, such as the initial lipid hydroperoxides and subsequent reactive toxic aldehydes, such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE)

Whereas MAMs seem to be more specific to Met than to Leu, the large subunit of IPMI the IPMI-LSU1 functions not only in aliphatic GSL biosynthesis but is still active in Leu biosynthesis (Knill et al., 2009

Simoes DC, Psarra AM, Mauad T, Pantou I, Roussos C, Sekeris CE, Gratziou C