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Munc13-4 polymorphism is associated with MAS, sJIA and systemic inflammation, while chronic TLR9 stimulation in mice develops features characteristic of MAS, including elevated serum levels of IFN, interleukin 6 (IL-6) and hepatic inflammation 10

Ou et al., 2005

DNA synthesis Essential for normal cell division 4

Thiazolidinediones are insulin sensitizers that function mostly through increasing insulin sensitivity in target organs such as the liver and muscles ( 3.1.1 Mode of action The activation of a transcription factor, peroxisome proliferator-activated receptor (PPAR), is the mechanism by which TZDs exert their anti-diabetic action