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Nitric oxide was found to be overexpressed in patients with UC, especially in the colonic mucosa leading to pathological changes in tissues, DNA damage, production of inflammatory cytokines, inhibition of the repair process, and elevating the risk of conversion of UC to colon cancer [Citation30,Citation31]

Potential role of epigenetic mechanism in manganese induced neurotoxicity

Shindo et al., 2008), PCR (Kusakabe et al., 1998

highlight how cytokines, growth factors, and paracrine signaling within the TME modulate DTP states by influencing intracellular signaling and transcriptional reprogramming ( Multiple studies have identified specific genes and signaling pathways underlying the DTP state