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GPX converts peroxides and hydroxyl radicals to non-toxic forms by oxidizing GSH to glutathione disulfide, which is then reduced to GSH by glutathione reductase ( The antioxidant response is modulated mainly by the Nrf2/Keap1 system (Figure 2)

NRF2 appears to be a key mechanistic link between circadian oscillations in redox balance and clock gene expression rhythms

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However, before it leaves our system, it does wreak significant havoc, significantly contributing to the negative effects of hangover.[3] The bodys ability to metabolize acetaldehyde, and the severity of its effects, largely depend on genetics.[3] The genetic factor, at least in this case, is absolute and unchangeable