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doi:10.1007/s12603-013-0023-x Saruhan E, Sertoglu E, Unal Y, Bek S, Kutlu G

Lipid peroxidation and ferroptosis promote bone loss in subchondral bone The modification of subchondral bone, including early-stage bone loss, late-stage bone sclerosis and histopathological alterations, plays an important role in the pathogenesis of OA [129]

As weve noted before, the function is dependent on structure, and the string of amino acids must fold into a specific 3-D shape, or conformation, in order to make a functional protein