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doi: 10.1212/WNL.0b013e3182a2cbd1 21 BousigesO.CretinB.MullerC.BotzungA.SannaL.AnthonyP.et al

Anchoring interactions with AGO2 MID ZSWIM8 residue F1261 docks at the centre of the MID-domain interface, and its mutation to alanine reduced AGO2 polyubiquitylation in vitro and abrogated TDMD in cells (Fig