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The majority of findings rely on in vitro experiments and animal models, which limits the ability to generalize results beyond controlled research environments

The pyruvate product was analyzed on SpectraMax i3 multimode plate reader through bottom reading (37 C, = 570 nm) with 30 min time interval

Considering ROS plays a crucial role in the degenerative NPCs during the IDD progression, we further investigate the microenvironmental ROS-scavenging performance of BP@CeO x nanozymes by measuring their reactivity with hydrogen peroxide (H 2 O 2 ), hydroxyl radical (OH) and superoxide radical (O 2 - )