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It regulates oxidative damage and attenuates the inflammatory state through anti-inflammatory enzymes and eliminating free radicals in the tissues

125 Despite this, the atheroprotective functions of 12/15-LOX-derived metabolites remain controversial, as 12/15-LOX-ApoE-double-deficient mice were found to be less prone to atherogenesis than ApoE / littermates with fully functional 12/15-LOX enzymes