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This study adds another tile to a possible therapeutic strategy for TBC1D24 -associated diseases, namely, combining agents that increase synaptic phosphatidyl-D-myo-inositol-4,5-bisphosphate (PI(4,5)P2) levels, which target TBC dysfunction, together with antioxidants, which target TLDc mutant hypersensitivity to ROS

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THALASSEMIA SYNDROMES The four classic thalassemias, most common in Asians, are thalassemia-2 trait, in which one of the four -globin loci is deleted