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The histological analysis was performed using a high power objective (x63) in the microscope ZEISS AXIOSKOP 2, by counting cells in three areas with a minimum of approximately 100 m 2 , using three distinct serial sections (50 m interval between sections) per animal, for five different animals

Additionally, synthesis of prodrugs like -glutamyl 3,4-dihydroxyphenylalanine (L-DOPA) has been reported to have increased half-life due to resistance to cleavage by general serum proteases (Hara et al., 1992