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Next, we reasoned that PrP distribution at the surface of polarized hepatocytes might be critical for its ability to drive Cu uptake in a physiological context

Meanwhile, the calcium/calmodulin-dependent protein kinase (CaMK) family, as the major Ca 2+ signal transducer, plays a crucial role in a variety of autophagy-related signaling pathways, including Ca 2+ -CaMKK-AMPK (Woods et al., 2005)-induced autophagy ( 2+ channels in various organelles, such as the lysosome or endoplasmic reticulum, have effects on autophagy ( A recent study has revealed that TRPV1-evoked Ca 2+ influx promotes CaMKII phosphorylation and subsequently promotes Nrf2 nuclear translocation (Lv et al., 2021)