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Other important pro-inflammatory signalling pathways regulated by ROS and in particular H 2 O 2 include p38-MAPK-mediated NF-B/HIF-1 82,83 , and JAK-STAT pathways 84

However, a validated testing protocol is needed to standardize the active constituents in the botanical drug products for use as an anti-UF treatment in ensuring a reproducible therapeutic effect

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doi: 10.3389/fimmu.2024.1331486 Received 01 November 2023 Accepted 19 February 2024 Published 06 March 2024 Volume 15 - 2024 Edited by Julio Villena, CONICET Reference Centre for Lactobacilli (CERELA), Argentina Reviewed by Claudio Nicoletti, University of Siena, Italy Rahul Shukla, National Institute of Pharmaceutical Education and Research, India Updates Copyright 2024 Yang, Hong, Zhang and Liu